An Overview of Variational Integrators

The purpose of this paper is to survey some recent advances in variational integrators for both finite dimensional mechanical systems as well as continuum mechanics. These advances include the general development of discrete mechanics, applications to dissipative systems, collisions, spacetime integration algorithms, AVI’s (Asynchronous Variational Integrators), as well as reduction for discrete mechanical systems. To keep the article within the set limits, we will only treat each topic briefly and will not attempt to develop any particular topic in any depth. We hope, nonetheless, that this paper serves as a useful guide to the literature as well as to future directions and open problems in the subject

The Impact of Human Assurance on Satellite Operations

Mission assurance is a method to guarantee mission success against a known set of risks; mission assurance is generally represented as a probability against a threshold of acceptable performance. Human assurance can be considered as the likelihood of acceptable operator performance given a set of conditions that include the operator, the system, and the environment. Standard mission assurance models tend to assume a qualified crew, but do not include other aspects of the internal or external environment that may impact the reliability of the human operator. A human assurance model can be created that allows the exploration of the variability in operator performance due to the likelihood of different risks. An example human assurance model has been created for the detection of adverse trending satellite data and the need to modify the existing mission schedule to address the satellite emergency. The model leverages the Human Viewpoint framework to capture the human-focused data within the mission context. From this data, sources of risk can be identified for the socio-technical system and a risk framework developed. The resulting risk model allows exploration of the characteristics of both the operator and the operating environment, as well as the impact of organizational mitigations, on the likelihood that the socio-technical system will meet mission assurance thresholds. The method provided can be used to identify the limitations of human system performance against the established criteria

Why is Austerity Governable? A Gramscian Urban Regime Analysis of Leicester, UK

open access articleAusterity has been delivered in the UK, without durably effective resistance. Read through a dialogue between Urban Regime Theory and Gramsci’s theory of the integral state, the paper considers how austerity was normalised and made governable in the city of Leicester. It shows how Leicester navigated waves of crisis, restructuring and austerity, positioning itself as a multicultural city of entrepreneurs. The paper explores historical influences on the development of the local state, inscribed in the politics of austerity governance today. From a regime-theoretical standpoint, it shows how the local state accrued the governing resources to deliver austerity, while disorganising and containing resistance. Imbued with legacies of past-struggles, this process of organised-disorganisation produced a functional hegemony articulated in the multiple subjectivities of “austerian realism”. The paper elaborates six dimensions of Gramscian regime analysis to inform further research

Dark-adapted red flash ERGs in healthy adults

Purpose: The x-wave of the dark-adapted (DA) ERG to a red flash reflects DA cone function. This exploratory study of healthy adults aimed to investigate changes in the DA red ERG with flash strength and during dark adaptation to optimise visualisation and therefore quantification of the x-wave. Methods: The effect of altering red flash strength was investigated in four subjects by recording ERGs after 20 minutes dark adaptation to red flashes (0.2–2.0 cd s m-2) using skin electrodes and natural pupils. The effect of dark adaptation duration was investigated in 16 subjects during 20 minutes in the dark, by recording DA 1.5 red ERGs at 1, 2, 3, 4, 5, 10, 15 and 20 minutes. Results: For a dark adaption period of 20 minutes, the x-wave was more clearly visualised to weaker (< 0.6 cd s m-2) red flash strengths: to stronger flashes it became obscured by the b-wave. For red flashes of 1.5 cd s m-2, the x-wave was most prominent in ERGs recorded after 1–5 minutes of dark adaptation: with longer dark-adaptation, it was subsumed into the b-wave’s rising edge. Conclusions: This small study suggests that x-wave visibility in healthy subjects after 20 minutes dark adaptation is improved by using flashes weaker than around 0.6 cd s m-2; for flash strengths of 1.5 cd s m-2, x-wave visibility is enhanced by recording after only around 5 minutes of dark adaptation. No evidence was found that interim red flash ERGs affecting the dark-adapted state of the normal retina

Romania\u27s Participation to the European Assessment Project Titled HyUnder, Multi-Criterial Analyses of Salt Cavern Locations

The scope of the work is to assess the potential, the actors and relevant business cases for large scale storage of renewable electricity by hydrogen underground storage in Romania. This presentation intends to provide a picture of the multi-criterial analyses of salt cavern locations in Romania. The energy sector is facing with the necessity to store large energy quantities for short to long term in order to adapt to the increasingly intermittent renewable energy. The results of this presentation have originated from an ongoing European assessment project by the name of HyUnder (FCH JU, grant 303417) regarding utilization of salt caverns for hydrogen underground storage. Currently, main uses of salt caverns include storage of hydrocarbons or wastes disposal. Salt caverns have stirred the interest of the scientific community regarding the potential applications in hydrogen economy. Romania has active mines or caverns and others closed, many of them have the potential to be used from hydrogen storage. These facts represent an interested situation in order to initiate studies or assessments of the potential hydrogen underground storage. The salt mines, hydrogen producers, renewable energy sources and research centers with high qualified scientists, represent essentially elements for new type of studies regarding hydrogen economy. In the context of scientific community\u27s efforts from Romania to assert active in the area of hydrogen technologies, this approach can certainly constitutes an attractive example for pan-European cooperation. The work disclaims the technic multi-criterial analyses of salt cavern locations regarding hydrogen underground storage. The introduction of hydrogen into economy offers the possibility to provide a number of advantages: sustainable development, valorization of local resources and improvement of competitiveness. The opportunities and viabilities of salt cavern locations are analyzed

Molecular and cellular limits to somatosensory specificity

Animals detect environmental changes through sensory neural mechanisms that enable them to differentiate the quality, intensity and temporal characteristics of stimuli. The 'doctrine of specific nervous energies' postulates that the different sensory modalities experienced by humans result of the activation of specific nervous pathways. Identification of functional classes of sensory receptors provided scientific support to the concept that somatosensory modalities (touch, pain, temperature, kinesthesis) are subserved by separate populations of sensory receptor neurons specialized in detecting innocuous and injurious stimuli of different quality (mechanical forces, temperature, chemical compounds). The identification of receptor proteins activated by different physicochemical stimuli, in particular ion channels of the Transient Receptor Potential (TRP) superfamily, has put forward the concept that specificity of peripheral sensory receptor neurons is determined by their expression of a particular "molecular sensor" that confers to each functional type its selectivity to respond with a discharge of nerve impulses to stimuli of a given quality. Nonetheless, recent experimental data suggest that the various molecular sensors proposed as specific transducer molecules for stimuli of different quality are not as neatly associated with the distinct functional types of sensory receptors as originally proposed. First, many ion channel molecules initially associated to the transduction of only one particular form of energy are also activated by stimuli of different quality, implying a limited degree of specificity in their transducing capacities. Second, molecular sensors associated with a stimulus quality and hence to a sensory receptor type and ultimately to a sensory modality may be concomitantly expressed in sensory receptor neurons functionally defined as specific for another stimulus quality. Finally, activation of voltage gated channels involved primarily in nerve impulse generation can also influence the gating of transducing channels, dramatically modifying their activation profile. Thus, we propose that the capacity exhibited by the different functional types of somatosensory receptor neurons to preferentially detect and encode specific stimuli into a discharge of nerve impulses, appears to result of a characteristic combinatorial expression of different ion channels in each neuronal type that finally determines their transduction and impulse firing properties. Transduction channels don't operate in isolation and their cellular context should also be taken into consideration to fully understand their function. Moreover, the inhomogeneous distribution of transduction and voltage-gated channels at soma, axonal branches and peripheral endings of primary sensory neurons influences the characteristics of the propagated impulse discharge that encodes the properties of the stimulus. Alteration of this concerted operation of ion channels in pathological conditions may underlie the changes in excitability accompanying peripheral sensory neuron injuries

A lung function information system

Abstract A lung function information system (LFIS) was developed for the data analysis of pulmonary function tests at different locations. This system was connected to the hospital information system (HIS) for the retrieval of patient data and the storage of the lung function variables of patients to generate follow-up reports and to support financial and administrative management. The application programs were developed in such a way that high flexibility was obtained with respect to the patient-computer-technician interaction. The sampled data are stored on a disc to correct earlier decisions, perform recalculations and reanalyse the data for research purposes. When the measurements performed on a patient are authorized, the sampled data are deleted, except for when they are needed for future research. A distributed computer system was chosen to combine the benefits of a centralized system with those of several stand-alone systems. The main tasks of the central unit are to store collected data and computer programs, generate a final lung function report on laser printer and provide a connection to the HIS. In the satellite computers, which are located close to the lung function equipment, the signals and raw data are processed. Furthermore, the satellite computers were in use for program development and several research projects, and for the offline data processing of the lung function measurements from two other hospitals by means of a modem connection. The LFIS improved the quantity and quality of data acquisition. It resulted in an increased capacity of about 50% concerning spirometry, and facilitated time-consuming complex analyses. It also avoided miscalculations and mistakes in reports previously experienced with hand calculations

Exploring Talenting: Talent Management as a Collective Endeavour

• Purpose We seek to show appreciation for the collective endeavour of work practices based on varying degrees of dependence, interdependence and mutuality between at least two people. Such dependencies have to be concerned with how talent is used and how this use is an interaction between people, a process we will call talenting. The aim of this paper is to provide a method to explore talenting. • Design/methodology/approach The paper will begin with a brief overview of recent debates relating to Talent Management and Development (TD). We argue that TMD seldom pays attention to work practices where performance is frequently a collective endeavour. We provide a case to explore talenting in West Yorkshire Police. A mapping method is explain to identify work practices and obtain narrative data. • Findings 12 examples are found and three are presented showing various forms of dependency to achieve outcomes. • Research limitations/implications TMD needs to move beyond employment practices to work practices. There is a need to close the gap between traditional TMD employment practices, usually individually focused, and work practices which are most likely to require a collective endeavour. • Practical implications There needs be ongoing appreciation of talenting to add to TMD activities. • Social implications We recognise a more inclusive approach to TMD • Originality/value Probably the first enquiry of its kind. Keywords – Talent Management and Development, Talenting, Collective Endeavour, Dependency and Interdependency

Evidence of Non-Thermal Particles in Coronal Loops Heated Impulsively by Nanoflares

The physical processes causing energy exchange between the Sun's hot corona and its cool lower atmosphere remain poorly understood. The chromosphere and transition region (TR) form an interface region between the surface and the corona that is highly sensitive to the coronal heating mechanism. High resolution observations with the Interface Region Imaging Spectrograph (IRIS) reveal rapid variability (about 20 to 60 seconds) of intensity and velocity on small spatial scales at the footpoints of hot dynamic coronal loops. The observations are consistent with numerical simulations of heating by beams of non-thermal electrons, which are generated in small impulsive heating events called "coronal nanoflares". The accelerated electrons deposit a sizable fraction of their energy in the chromosphere and TR. Our analysis provides tight constraints on the properties of such electron beams and new diagnostics for their presence in the nonflaring corona.Comment: Published in Science on October 17: http://www.sciencemag.org/content/346/6207/1255724 . 26 pages, 10 figures. Movies are available at: http://www.lmsal.com/~ptesta/iris_science_mov

A Mutant Ahr Allele Protects the Embryonic Kidney from Hydrocarbon-Induced Deficits in Fetal Programming

Background: The use of experimental model systems has expedited the elucidation of pathogenetic mechanisms of renal developmental disease in humans and the identification of genes that orchestrate developmental programming during nephrogenesis